it's not a problem, it's just a lot more work. SDE's would not be possible with RED.
You have to take the RAW files, do a one-light pass and re-encode for editing. Then, after the editing, you process the raw files that you're going to use, render those out, then resize them down to 1080 or 720, then pull them back into your editor or into your final output software, then render your movie. And even on a geeked-out MacPro, we would have to remember to render our dailies the night of the shoot so they'd hopefully be ready in the morning for editing. they take a lot longer to re-encode or render than the easy process of the 5D files.
with that said, there may be advances now for editing the red files natively so you can skip the first step. it's been a while since i've shot on red.
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