That should not be a problem. As with any source unit, you have to find the point where distortion is produced. The distortion can be from the HU itself, or from the inputs of the processor, it doesn't really matter. Then make sure you never exceed that particular volume level.
Mobridge DA2 > JBL MS-8 > JL Audio HD600/4 > (3) Hybrid Audio L3SE & (2) Rainbow Cal25; JL Audio HD900/5 > (2) Morel HCW-10 & (1) AE SBP15