I've gone thru potholes where I am the only survivor when there are 5-6 casualties on the side if the road. Plus even if I got a flat from a pothole I will most likely be able to drive off to gas station for safety, vs side of the 70mph highway.
Obviously, the slimmer the side-wall the more direct impact to the rim as well. The third gen potenza pole position rfts are a little different construction. I hear much better in ride quality.