If you introduce a different driver into the front stage, MS-8 will have to correct both level and EQ in order to compensate for the center speaker's differences. With limited power (30W per channel), you could very easily lose a lot of headroom, and run into issues with low system volume and distortion.
Besides, JBL won an IASCA SQ event with the MS-8 and the OEM L7 speakers (plus tweeters for the center and rear doors), so it's not like these speakers won't work well together.
Now if we're talking external amps, then I would say go ahead and put the best speaker in there you can find.
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Mobridge DA2 > JBL MS-8 > ARC XDi 600/4 > JBL Gti 408 Mids & Vifa OT19 Tweeters; PG Ti2 1600.5 > Morel HCW-10 & IDMax 15
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