Man, the hotels are endless. Assuming you're on the younger side and looking for something trendy and not fit for royalty:
Gansevoort-Meatpacking or Park Ave
http://www.hotelgansevoort.com/
http://www.gansevoortpark.com/
Trump Soho
http://www.trumphotelcollection.com/soho/
Mariott Marquis, although not glamorous DEF. in the heart of everything. Revolving restaurant (crap) and lounge on the 52nd floor or something
http://www.marriott.com/hotels/trave...riott-marquis/
Tribeca grand
http://www.tribecagrand.com/
Great spot across the river into Long Island City but you would have to jump across the river everyday
http://www.zhotelny.com/
Gramercy Park hotel
http://www.gramercyparkhotel.com/
The Standard in Meatpacking disctrict (very young hip crowd)
http://standardhotels.com/high-line
Hotel on Rivington
http://www.hotelonrivington.com/
The Kimberly hotel (good rooftop brunch spot)
http://www.kimberlyhotel.com/
Shall I go on?
Heres some great dining advice too:
http://forum.e46fanatics.com/showthr...ht=restaurants
http://forum.e46fanatics.com/showthr...ht=restaurants